This text was created to fill a void in the practice of pediatric neuropathology. It is a practical and well-illustrated book representing a collection of interesting, common and unusual tumors for a diagnostic exercise by the reader. The wide reception of the first edition by the pathology community is testament to its relevance and utility in the pathologic diagnosis of pediatric brain tumors. This edition covers topics ranging from neuroimaging, the use of crush and touch preps during intraoperative consultation, classic histological features of pediatric brain tumors, tumor variants, and a miscellaneous group of challenging tumors. Chapters consist of essential diagnostic information and features highlighting recognized variants and their differential diagnoses. A section on molecular pathology and electron microscopy is also included for each tumor category, along with a list of classic reviews and innovative articles on each of the tumor entities as suggested reading at the end of each chapter.Atlas of Pediatric Brain Tumors, Second Edition represents the state of the art in pediatric neuropathology with easy utility beside the microscope.

Adekunle Michael Adesina, MDDirector of Neuropathology& Molecular Neuropathology Laboratory

Texas Children's Hospital

Dr. Adesina's primary interest is in the clinical and molecular genetics of pediatric brain tumors with special interest in medulloblastoma. He is involved in ongoing collaborative studies with the pediatric brain tumor group of the Hematology/Oncology division. He is also a collaborator with others on the genomic profiling of embryonal pediatric tumors and the role of FoxG1 in determining susceptibility to these embryonal tumors.

TABLE OF CONTENTS

 

1 Introduction and Overview of Brain Tumors 

Adekunle M. Adesina

 

Section I: Glial Tumors

2 Pilocytic Astrocytoma and Pilomyxoid Astrocytoma

Christine E. Fuller

 

3 Pleomorphic Xanthoastrocytoma

Christine E. Fuller

 

4 Infiltrative Astrocytomas (Diffuse Astrocytoma, Anaplastic Astrocytoma, Glioblastoma)

Christine E. Fuller

5 Oligodendroglial Tumors

Hope T. Richard, Christine E. Fuller

 

6 Ependymal Tumors

Christine E. Fuller                  

 

Section II: Embryonal Neuroepithelial Tumors

 

7 Central Nervous System Primitive Neuroectodermal Tumors (PNETs) and Medulloepithelioma

Adekunle M. Adesina, Jill V. Hunter, Lucy Rorke-Adams

8 Medulloblastoma

Adekunle M. Adesina, Jill V. Hunter

 

9 Atypical Teratoid/Rhabdoid Tumor

Adekunle M. Adesina, Jill V. Hunter, Lucy Rorke-Adams

 

Section III: Tumors of the Meninges

 10 Meningioma

Christine E. Fuller

 

11 Hemangiopericytoma and Other Mesenchymal Tumors

Christine E. Fuller

12 Melanocytic Lesions

Christine E. Fuller

13 Hemangioblastoma Hope T. Richard, Christine E. Fuller

 

Section IV: Tumors of Cranial and Spinal Nerves

14 Schwannoma

Tarik Tihan

15 Neurofibroma

Tarik Tihan

16 Malignant Peripheral Nerve Sheath Tumors

Yazgi Koy, Tarik Tihan

           

Section V: Neuronal and Mixed Neuronal-Glial Tumors

 

17        Desmoplastic Infantile Astrocytoma and Ganglioglioma

Adekunle M. Adesina

 

18 Dysembryoplastic Neuroepithelial Tumor

Adekunle M. Adesina, Ronald Rauch

 

19 Gangliocytoma and Ganglioglioma

Carrie A. Mohila, Ronald Rauch, Adekunle M. Adesina

20 Central Neurocytoma and Extraventricular Neurocytoma

Carrie A. Mohila, Ronald Rauch, Adekunle M. Adesina

21 Papillary Glioneuronal Tumor

Marie Rivera-Zengotita, Anna Illner, Adekunle M. Adesina                                                             

22 Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle

Marie Rivera-Zengotita, Adekunle M. Adesina

23 Malignant Epithelioid Glioneuronal Tumor

Marie Rivera-Zengotita, Ronald Rauch, Adekunle M. Adesina

24 Paraganglioma

Andreana L. Rivera, Adekunle M. Adesina

 

Section VI: Neurocutaneous Syndromes

 

25 Neurofibromatosis 1

Tarik Tihan

 

26 Neurofibromatosis 2

Tarik Tihan

 

27 Von Hippel-Lindau Disease

Tarik Tihan, Adekunle M. Adesina

 

28 Tuberous Sclerosis Complex

Tarik Tihan, Adekunle M. Adesina

29 Lhermitte-Duclos Disease and Cowden Disease

Hidehiro Takei, Hiroyoshi Suzuki, Adekunle M. Adesina

           

Section VII: Tumors in the Region of the Pituitary Fossa

30 Pituitary Adenomas

Yazgi Koy, Tarik Tihan

31 Rare Pituitary Tumors Other Than AdenomasYazgi Koy, Tarik Tihan32 Adamantinomatous Craniopharyngioma

Tarik Tihan

Section VIII: Choroid Plexus Neoplasms

 

33 Choroid Plexus Neoplasms

Christine E. Fuller

Section IX: Pineal-Based Tumors

 

34 Pineal Parenchymal Tumors

Tarik Tihan

 

Section X: Germ Cell Tumors

 

35 Germ Cell Tumors

Tarik Tihan

           

Section XI: Paraneoplastic Disorders

 

36 Paraneoplastic Disorders of the Central Nervous System

Christine E. Fuller

 

 

Section XII: Tumours of the Hematopoietic System

 

37 Malignant Lymphomas

Adekunle M. Adesina

 

38 Histiocytic Tumors

Abir Mukherjee

Adekunle M. Adesina

 

Section XIII: Interesting or Challenging Cases and Exercises in Pattern Recognition

 

39 Case Studies

Adekunle M. Adesina, Christine E. Fuller, Lucy Rorke-Adams